Team SOMo


« Synthèse Organique et diversité Moléculaire pour le vivant »

SchassaingStefan CHASSAING

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Scientific objective

The SOMo team is a chemistry group whose research efforts are focused on the design/development of chemical tools:

      • for organic synthesis within the Green Chemistry context (methodologies, alternative reagents/solvents, supported catalysis),
      • for diagnosis and therapeutics (fluorescence/luminescence, drug-delivery, nanomedicine, photoactivatable probes, chemical biology).

In particular, the team is involved in diverse projects using nanomaterials:

      • for catalytic applications with zeolites as ‘green’ nanoreactors,

        IMAGE1 ZEO

      • for biological applications as diagnostic/therapeutic nanotools.

        somo2

Team members

Stefan CHASSAING (MCU), Christian LHERBET (CR1), Romain AURIOU (M2R-Chimie TOULOUSE), Fabien UGO (M2R-Chimie TOULOUSE), Nezha NASRAOUI (M2I-Chimie Santé TOULOUSE, co-supervision with BIOMAPS Team-ITAV), Charlène DE CONTO (M2I-Chimie Santé TOULOUSE, co-supervision with IDeAS Team-IMRCP).

Expected outcomes

Develop novel (photoactivatable) fluorescent molecules/materials for biological imaging

Elaborate novel synthetic methodologies in accordance with "green chemistry" principles and/or ready-to-be automated.

Keywords

Organic synthesis, fluorescent probes, synthetic methods, "green chemistry", nanomaterials, chemical biology

Cooperations, partnerships and valorisation

  • Patrick PALE, Institut de Chimie, Univ STRASBOURG
  • Stéphane QUIDEAU, ISM, Univ BORDEAUX
  • Jean-Daniel MARTY, IMRCP, Univ TOULOUSE
  • Fernando PINA, Universidade NOVA de LISBOA (PORTUGAL)
  • Valérie LOBJOIS, IP3D Team, ITAV
  • Mathieu DANEL, Plateforme Chimie, ITAV
  • Béatrice MESTRE-VOEGTLE and Christelle HUREAU, BIOMAPS Team, ITAV

Funding:

fondation anr

 

 


   

 

Recent publications

 


 

  • NM Pinkerton, L. Behar, K. Hadri, B. Amouroux, C. Mingotaud, DR Talham, S. Chassaing*, JD Marty* Ionic Flash Nanoprecipitation (iFNP) for the Facile, One-Step Synthesis of Inorganic-Organic Hybrid Nanoparticles in Water, Nanoscale, in press, DOI:10.1039/C6NR09364G
  • S. Chassaing, V. Bénéteau, B. Louis, P. Pale Zeolites as Green Catalysts for Organic Synthesis : the Cases of H-, Cu- & Sc-Zeolites, Curr. Org. Chem. in press, DOI: 10.2174/1385272820666160525130204
  • T. Garnier, R. Sakly, M. Danel, S. Chassaing*, P. Pale* Chan-Lam-Type C-N Cross-Coupling Reactions under Base- and Ligand-Free CuI-Zeolite Catalysis, Synthesis, in press, DOI: 10.1055/s-0036-1588652
  • S. Chaabouni., F. Simonet, A. François, S. Abid., C. Galaup, S. Chassaing* 3-Trifluoromethylated Coumarins via Radical Trifluoromethylation of ortho-Hydroxycinnamic Esters, Eur. J. Org. Chem. in press, DOI: 10.1002/ejoc.201601181
  • S. D. Joshi S.R Dixit, V.H Kulkarni, C. Lherbet, M. Nadagouda, T.M. Aminabhavi, Synthesis, biological evaluation and in silico molecular modeling of pyrrolyl benzohydrazide derivatives as enoyl ACP reductase inhibitors.  Eur. J. Med. Chem. 2017, 126, 286-297.
  • N. Basilio, T. Garnier, J. Avò, M. Danel, S. Chassaing*, F. Pina* Synthesis and Multistate Characterization of Bis-Flavylium Dications – Symmetric Resorcinol- and Phloroglucinol-Type Derivatives as Stochastic Systems, RSC Adv. 2016, 6, 69698-669707
  • NM Pinkerton, C. Frongia, V. Lobjois, BK Wilson, MJ Bruzek, RK Prud’homme, J. Anthony, F. Bolze, S. Chassaing* Red-Emitting EtTP-5-Based Organic Nanoprobes for Two-Photon Imaging in 3D Multicellular Biological Models, RSC Adv. 2016, 6, 65770-65774
  • D. Kumar, S.R. Dixit, N. Tigadi, U.A. More, C. Lherbet, T.M. Aminabhavi, K.S Yang, Synthesis, characterization and antitubercular activities of novel pyrrolyl hydrazones and their Cu-complexes,  Eur. J. Med. Chem. 2016, 121, 21-39.
  • D. Veau., S. Krykun.,G.  Mori, BS Orena, MR Pasca, C. Frongia., V. Lobjois, S. Chassaing.,* C. Lherbet, M. Baltas Triazolophthalazines – Easily Accessible Compounds with Potent Antitubercular Activity ChemMedChem, 2016, 11, 1078-1089
  • S. Chassaing., V. Bénéteau., P. Pale  When CuAAC 'Click Chemistry' goes Heterogeneous, Catal. Sci. Technol. 2016, 6, 923-957
  • Carbenes and Nitrenes, S. Chassaing and E. Gras, In Organic Reaction Mechanisms - 2013,. AC Knipe Ed.; Wiley, 2016, 177-218
  • V. Magné, T. Garnier, M. Danel, P. Pale, S. Chassaing* CuI-USY as a Ligand-Free and Recyclable Catalytic System for the Ullmann-Type Diaryl Ether Synthesis, Org. Lett. 2015, 17, 4494-4497
  • Carbenes and Nitrenes, S. Chassaing and E. Gras, In Organic Reaction Mechanisms - 2012,. AC Knipe Ed.; Wiley, 2015, 171-208
  • S. Chassaing S.*, G. Isorez-Mahler, M. Kueny-Stotz, R. Brouillard Aged Red Wine Pigments as a Source of Inspiration for Organic Synthesis - The cases of the Color-Stable Pyranoflavylium & (Flavylium-(4-8)-Flavan Chromophores, Tetrahedron 2015, 71, 3066-3078
  • Carbenes and Nitrenes, S. Chassaing and E. Gras, In Organic Reaction Mechanisms - 2011,. AC Knipe Ed.; Wiley, 2014, 199-231

“Synthesis, biological evaluation and in silico molecular modeling of pyrrolyl benzohydrazide derivatives as enoyl ACP reductase inhibitors”. S. D. Joshi S.R Dixit, V.H Kulkarni, C. Lherbet, M. Nadagouda, T.M. Aminabhavi, Eur. J. Med. Chem. 2017, 126, 286-297.